1,428 research outputs found
Giant anharmonicity suppresses superconductivity in AlH under pressure
The anharmonic self energy of two zone boundary phonons were computed to
lowest order for AlH in the structure at 110 GPa. The
wavevector and branch index corresponding to these modes are situated in a
region of phase space providing most of the electron-phonon coupling. The self
energies are found to be very large and the anharmonic contribution to the
linewidth of one of the modes studied could be distinguished from the
electron-phonon linewidth. It is found that anharmonicity suppresses the
electron-phonon coupling parameter , providing a possible explanation
for the disagreement between experiment and previous theoretical studies of
superconductivity in this system.Comment: 10 pages, 4 figure
Efficient dielectric matrix calculations using the Lanczos algorithm for fast many-body implementations
We present a implementation that assesses the two major bottlenecks
of traditional plane-waves implementations, the summations over conduction
states and the inversion of the dielectric matrix, without introducing new
approximations in the formalism. The first bottleneck is circumvented by
converting the summations into Sternheimer equations. Then, the novel avenue of
expressing the dielectric matrix in a Lanczos basis is developed, which reduces
the matrix size by orders of magnitude while being computationally efficient.
We also develop a model dielectric operator that allows us to further reduce
the size of the dielectric matrix without accuracy loss. Furthermore, we
develop a scheme that reduces the numerical cost of the contour deformation
technique to the level of the lightest plasmon pole model. Finally, the use of
the simplified quasi-minimal residual scheme in replacement of the conjugate
gradients algorithm allows a direct evaluation of the corrections at
the desired real frequencies, without need for analytical continuation. The
performance of the resulting implementation is demonstrated by
comparison with a traditional plane-waves implementation, which reveals a
500-fold speedup for the silane molecule. Finally, the accuracy of our
implementation is demonstrated by comparison with other calculations
and experimental results.Comment: 19 pages, 2 figure
Anharmonic stabilization of the high-pressure simple cubic phase of calcium
The phonon spectrum of the high-pressure simple cubic phase of calcium, in
the harmonic approx- imation, shows imaginary branches that make it
mechanically unstable. In this letter, the phonon spectrum is recalculated
using density-functional theory (DFT) ab initio methods fully including
anharmonic effects up to fourth order at 50 GPa. Considering that perturbation
theory cannot be employed with imaginary harmonic frequencies, a variational
procedure based on the Gibbs- Bogoliubov inequality is used to estimate the
renormalized phonon frequencies. The results show that strong quantum
anharmonic effects make the imaginary phonons become positive even at zero
temperature so that the simple cubic phase becomes mechanically stable, as
experiments suggest. Moreover, our calculations find a superconducting Tc in
agreement with experiments and predict an anomalous behavior of the specific
heat.Comment: 5 pages, 3 figure
Interstitial Electronic Localization
We investigate the ground-state properties of a collection of \textit{N}
non-interacting electrons in a macroscopic volume also containing a
crystalline array of \textit{N} spheres of radius each taken as largely
impenetrable to electrons and with proximity of neighboring excluding regions
playing a key physical role. The sole parameter of this quantum system is the
ratio , where is the Wigner- Seitz radius. Two lattices (FCC and
BCC) are selected to illustrate the behavior of the system as a function of
. As this ratio increases valence electrons localize in the
interstitial regions and the relative band-width is
found to decrease monotonically for both. The system is motivated by the
behavior of the alkali metals at significant compression. It accounts for band
narrowing, leads to electronic densities with interstitially centered maxima,
and can be taken as a model which clearly may be improved upon by perturbation
and other methods.Comment: 11 pages, 5 figure
CFD-based functional imaging for arteries: in vitro validation
De l’imagerie fonctionnelle pour les
vaisseaux est développée à partir de données médicales morphologiques (IRM 4D) et
hémodynamiques (IRM par contraste de phase dans les plans d’entrée-sortie). Les données
fonctionnelles pertinentes (champ de vitesse, frottement pariétal, gradient de
pression,…) sont alors calculées en simulant l’écoulement compatible avec les données
médicales. On présente les résultats obtenus dans la phase de validation in vitro de
cette technique sur un fantôme de crosse aortique
Cross-checking to reduce adverse events resulting from medical errors in the emergency department: study protocol of the CHARMED cluster randomized study
International audienceBackgroundMedical errors and preventable adverse events are a major cause of concern, especially in the emergency department (ED) where its prevalence has been reported to be roughly of 5–10 % of visits. Due to a short length of stay, emergency patients are often managed by a sole physician – in contrast with other specialties where they can benefit from multiples handover, ward rounds and staff meetings. As some studies report that the rate and severity of errors may decrease when there is more than one physician involved in the management in different settings, we sought to assess the impact of regular systematic cross-checkings between physicians in the ED.DesignThe CHARMED (Cross-checking to reduce adverse events resulting from medical errors in the emergency department) study is a multicenter cluster randomized study that aim to evaluate the reduction of the rate of severe medical errors with implementation of systematic cross checkings between emergency physician, compared to a control period with usual care. This study will evaluate the effect of this intervention on the rate of severe medical errors (i.e. preventable adverse events or near miss) using a previously described two-level chart abstraction. We made the hypothesis that implementing frequent and systematic cross checking will reduce the rate of severe medical errors from 10 to 6 % - 1584 patients will be included, 140 for each period in each center.DiscussionThe CHARMED study will be the largest study that analyse unselected ED charts for medical errors. This could provide evidence that frequent systematic cross-checking will reduce the incidence of severe medical errors
321. Deletion of Mutated GAA Repeats from the Intron 1 of the Frataxin Gene Using the CRISPR System Restores the Protein Expression in a Friedreich Ataxia Model
The CRISPR system is now widely used as a molecular tool to edit the genome. We used this technique in Friedreich Ataxia (FRDA), an inherited autosomal disease known to cause a decrease of the mitochondrial frataxin protein. Genetic analysis revealed a GAA repeat expansion within the intron 1 of the frataxin (FXN) gene. We used cells derived from the YG8sR mouse model where the mouse frataxin gene is knockout but contain a human FXN mutated transgene on one allele. We then deleted the GAA trinucleotide repeat using 2 specific guide RNAs (gRNAs) co-expressed with either S. pyogenes (Sp) or S. aureus (Sa) Cas9. We were able to monitored an increase up to 2-fold of frataxin mRNA and protein levels in clone cells. We also confirmed these results in vivo using DNA electroporation in the Tibialis anterior muscle of the YG8R mice. Ongoing in vivo investigation of a systemically injected AAV-DJ vector expressing the SaCas9 and 2 successful selected gRNAs in the mouse model YG8sR will hopefully provide more details answers on the efficacy of the approach and give us preliminary data to go forward for clinical trial. The deletion of the GAA repeats expansion then might be a highly valuable gene therapy approach for FRDA patients
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